Skin fibroblasts and tumor fibroblasts were extracted from a 64-year old male patient clinically diagnosed with laryngeal carcinoma.Control and tumor specific induced pluripotent stem cells were reprogrammed with 5 reprogramming factors, Klf-4, c-Myc, Oct-4, Sox-2, and Lin-28, a&d ej-123 using the messenger RNA reprogramming system.The transgene-free iPSC lines showed merlin wizard costume pluripotency, confirmed by immunofluorescence staining.The iPSC lines also showed normal karyotype, and could form embryoid bodies in vitro and differentiate into the 3 germ layers in vivo.This in vitro cellular model can be used to study the oncogenesis and pathogenesis of laryngeal carcinoma.